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var(--med-focus-ring-color);outline-offset:var(--med-focus-ring-offset)}:where(a[href],area[href],button:not(:disabled),input:not(:disabled),select:not(:disabled),textarea:not(:disabled),summary,[tabindex]:not([tabindex="-1"])):focus:not(:focus-visible){outline:none}.sr-only{clip:rect(0,0,0,0);clip-path:inset(50%);white-space:nowrap;border:0;width:1px;height:1px;margin:-1px;padding:0;position:absolute;overflow:hidden}.touch-target{min-inline-size:var(--med-touch-target-minimum);min-block-size:var(--med-touch-target-minimum)}.touch-target-compact{min-inline-size:var(--med-touch-target-compact);min-block-size:var(--med-touch-target-compact)}.skip-link{z-index:var(--med-layer-toast);min-inline-size:var(--med-touch-target-minimum);min-block-size:var(--med-touch-target-minimum);padding-inline:var(--med-space-4);border:var(--med-border-default);border-radius:var(--med-radius-md);background:var(--med-color-background-surface);color:var(--med-color-text-link);box-shadow:var(--med-elevation-floating);font-size:var(--med-type-label-size);font-weight:var(--med-type-weight-semibold);line-height:var(--med-type-label-leading);transform:translateY(calc(-100% - var(--med-space-8)));justify-content:center;align-items:center;text-decoration:none;display:inline-flex;position:fixed;inset-block-start:calc(var(--med-safe-area-top) + var(--med-space-2));inset-inline-start:calc(var(--med-safe-area-left) + var(--med-space-2))}.skip-link:focus{transform:translateY(0)}@media (forced-colors:active){:where(a[href],area[href],button:not(:disabled),input:not(:disabled),select:not(:disabled),textarea:not(:disabled),summary,[tabindex]:not([tabindex="-1"])):focus-visible{outline-color:highlight}}@media (prefers-reduced-motion:reduce){:root{--med-motion-duration-fast:.01ms;--med-motion-duration-standard:.01ms;--med-motion-duration-deliberate:.01ms}html:focus-within{scroll-behavior:auto}*,:after,:before{scroll-behavior:auto!important;transition-duration:.01ms!important;animation-duration:.01ms!important;animation-iteration-count:1!important}}:root{--med-control-height-sm:2.75rem;--med-control-height-md:2.875rem;--med-control-height-lg:3.25rem;--med-control-padding-sm:var(--med-space-3);--med-control-padding-md:var(--med-space-4);--med-control-padding-lg:var(--med-space-5)}.ui-button,.ui-icon-button{justify-content:center;align-items:center;gap:var(--med-space-2);border:var(--med-border-width-default) var(--med-border-style) transparent;border-radius:var(--med-radius-md);font-weight:var(--med-type-weight-semibold);white-space:nowrap;cursor:pointer;transition-property:background-color,border-color,color,box-shadow,transform;transition-duration:var(--med-motion-duration-fast);transition-timing-function:var(--med-motion-easing-standard);flex-shrink:0;line-height:1;text-decoration:none;display:inline-flex}.ui-button:active:not(:disabled),.ui-icon-button:active:not(:disabled){transform:translateY(1px)}.ui-button:disabled,.ui-icon-button:disabled{background:var(--med-color-action-disabled);color:var(--med-color-action-disabled-foreground);box-shadow:none;cursor:not-allowed;border-color:#0000;transform:none}.ui-button--sm,.ui-icon-button--sm{min-block-size:var(--med-control-height-sm);font-size:var(--med-type-body-sm-size)}.ui-button--md,.ui-icon-button--md{min-block-size:var(--med-control-height-md);font-size:var(--med-type-body-size)}.ui-button--lg,.ui-icon-button--lg{min-block-size:var(--med-control-height-lg);font-size:var(--med-type-body-size)}.ui-button--sm{padding-inline:var(--med-control-padding-sm)}.ui-button--md{padding-inline:var(--med-control-padding-md)}.ui-button--lg{padding-inline:var(--med-control-padding-lg)}.ui-button--primary{border-color:var(--med-color-action-primary-highlight);background:var(--med-color-action-primary);color:var(--med-color-action-primary-foreground);box-shadow:var(--med-elevation-action)}.ui-button--primary:hover:not(:disabled){border-color:var(--med-color-brand-accent)}@supports (color:color-mix(in lab,red,red)){.ui-button--primary:hover:not(:disabled){border-color:color-mix(in srgb,var(--med-color-brand-accent) 14%,var(--med-color-action-primary-hover))}}.ui-button--primary:hover:not(:disabled){background:var(--med-color-action-primary-hover);box-shadow:var(--med-elevation-action-hover)}.ui-button--primary:active:not(:disabled){border-color:var(--med-color-brand-accent)}@supports (color:color-mix(in lab,red,red)){.ui-button--primary:active:not(:disabled){border-color:color-mix(in srgb,var(--med-color-brand-accent) 10%,var(--med-color-action-primary-active))}}.ui-button--primary:active:not(:disabled){background:var(--med-color-action-primary-active);box-shadow:var(--med-elevation-action-active)}.ui-button--secondary{border-color:var(--med-color-border-default);background:var(--med-color-background-surface);color:var(--med-color-text-link);box-shadow:var(--med-elevation-surface)}.ui-button--secondary:hover:not(:disabled){border-color:var(--med-color-border-strong);background:var(--med-color-action-primary-subtle)}.ui-button--secondary:active:not(:disabled){background:var(--med-color-action-primary-subtle-hover)}.ui-button--tertiary{color:var(--med-color-text-link);background:0 0}.ui-button--tertiary:hover:not(:disabled){background:var(--med-color-action-primary-subtle)}.ui-button--tertiary:active:not(:disabled){background:var(--med-color-action-primary-subtle-hover)}.ui-button__icon{justify-content:center;align-items:center;font-size:1.1em;display:inline-flex}.ui-icon-button{inline-size:var(--med-control-height-md);border-color:var(--med-color-border-default);background:var(--med-color-background-surface);color:var(--med-color-text-link);box-shadow:var(--med-elevation-surface);padding:0}.ui-icon-button:hover:not(:disabled){border-color:var(--med-color-border-strong);background:var(--med-color-action-primary-subtle)}.ui-icon-button--sm{inline-size:var(--med-control-height-sm)}.ui-icon-button--lg{inline-size:var(--med-control-height-lg)}.ui-spinner{flex:none;justify-content:center;align-items:center;display:inline-flex}.ui-spinner--sm{block-size:1rem;inline-size:1rem}.ui-spinner--md{block-size:1.25rem;inline-size:1.25rem}.ui-spinner--lg{block-size:1.75rem;inline-size:1.75rem}.ui-spinner__indicator{border:2px solid;block-size:100%;inline-size:100%}@supports (color:color-mix(in lab,red,red)){.ui-spinner__indicator{border:2px solid color-mix(in srgb,currentcolor 28%,transparent)}}.ui-spinner__indicator{border-radius:var(--med-radius-full);animation:med-spinner var(--med-motion-duration-deliberate) linear infinite;border-block-start-color:currentColor}@keyframes med-spinner{to{transform:rotate(1turn)}}.ui-skeleton-loader{gap:var(--med-space-3);inline-size:100%;display:grid}.ui-skeleton{background:var(--med-color-border-subtle);max-inline-size:100%;display:block}.ui-skeleton--text{border-radius:var(--med-radius-xs);min-block-size:.875rem}.ui-skeleton--rectangle{border-radius:var(--med-radius-md);min-block-size:4rem}.ui-skeleton--circle{aspect-ratio:1;border-radius:var(--med-radius-full);min-block-size:2.5rem;min-inline-size:2.5rem}.ui-card{inline-size:100%;padding:var(--med-space-6);border:var(--med-border-default);border-radius:var(--med-radius-lg);background:var(--med-color-background-surface);color:var(--med-color-text-primary);text-align:start;display:block}.ui-card--elevated{border-color:var(--med-color-border-subtle);box-shadow:var(--med-elevation-raised)}.ui-card--interactive{min-block-size:var(--med-touch-target-minimum);font:inherit;cursor:pointer;transition-property:background-color,border-color,box-shadow,transform;transition-duration:var(--med-motion-duration-standard);transition-timing-function:var(--med-motion-easing-standard);text-decoration:none}.ui-card--interactive:hover:not(:disabled){border-color:var(--med-color-border-strong);background:var(--med-color-background-subtle);box-shadow:var(--med-elevation-raised);transform:translateY(-1px)}.ui-card--interactive:active:not(:disabled){transform:translateY(0)}.ui-card--interactive:disabled{color:var(--med-color-text-disabled);cursor:not-allowed}.ui-field{gap:var(--med-space-2);inline-size:100%;display:grid}.ui-field__heading{justify-content:space-between;align-items:baseline;gap:var(--med-space-3);min-inline-size:0;display:flex}.ui-field__label{color:var(--med-color-text-primary);font-size:var(--med-type-label-size);font-weight:var(--med-type-weight-semibold);line-height:var(--med-type-label-leading)}.ui-field__indicator{color:var(--med-color-text-muted);font-size:var(--med-type-caption-size);font-weight:var(--med-type-weight-medium);line-height:var(--med-type-caption-leading);flex:none}.ui-field__description,.ui-field__error{font-size:var(--med-type-body-sm-size);line-height:var(--med-type-body-sm-leading);margin:0}.ui-field__description{color:var(--med-color-text-muted)}.ui-field__error{align-items:flex-start;gap:var(--med-space-2);color:var(--med-color-status-danger-foreground);display:flex}.ui-field__error-marker{border-radius:var(--med-radius-full);block-size:1rem;inline-size:1rem;font-size:.625rem;font-weight:var(--med-type-weight-semibold);border:1px solid;flex:none;justify-content:center;align-items:center;margin-block-start:.1875rem;line-height:1;display:inline-flex}.ui-input-group,.ui-input-shell{border:var(--med-border-default);border-radius:var(--med-radius-md);background:var(--med-color-background-surface);inline-size:100%;transition-property:background-color,border-color,box-shadow;transition-duration:var(--med-motion-duration-fast);transition-timing-function:var(--med-motion-easing-standard);grid-template-columns:auto minmax(0,1fr) auto;display:grid;position:relative;overflow:hidden}.ui-input-group:hover:not([data-disabled=true]):not([data-read-only=true]){border-color:var(--med-color-border-strong)}.ui-input-group:focus-within{border-color:var(--med-color-border-focus);outline:var(--med-focus-ring-width) solid var(--med-focus-ring-color);outline-offset:var(--med-focus-ring-offset)}@media (forced-colors:active){.ui-input-group:focus-within{outline-color:highlight}}.ui-input-group[data-invalid=true]{border-color:var(--med-color-status-danger-foreground)}.ui-input-group[data-disabled=true]{border-color:var(--med-color-border-subtle);background:var(--med-color-action-disabled)}.ui-input-group[data-read-only=true]{border-color:var(--med-color-border-subtle);background:var(--med-color-background-subtle)}.ui-input-group__affordance{max-inline-size:40%;color:var(--med-color-text-muted);font-size:var(--med-type-body-sm-size);font-weight:var(--med-type-weight-medium);pointer-events:none;text-overflow:ellipsis;white-space:nowrap;align-items:center;line-height:1;display:inline-flex;overflow:hidden}.ui-input-group__affordance--leading{grid-column:1;padding-inline-start:var(--med-space-4)}.ui-input-group__affordance--trailing{grid-column:3;padding-inline-end:var(--med-space-4)}.ui-input,.ui-textarea{border:var(--med-border-default);border-radius:var(--med-radius-md);background:var(--med-color-background-surface);inline-size:100%;color:var(--med-color-text-primary);font-size:var(--med-type-body-size);line-height:var(--med-type-body-leading);transition-property:background-color,border-color,box-shadow;transition-duration:var(--med-motion-duration-fast);transition-timing-function:var(--med-motion-easing-standard);display:block}.ui-input::placeholder,.ui-textarea::placeholder{color:var(--med-color-text-muted);opacity:1}.ui-input:hover:not(:disabled),.ui-textarea:hover:not(:disabled){border-color:var(--med-color-border-strong)}.ui-input:focus,.ui-textarea:focus{border-color:var(--med-color-border-focus)}.ui-input-group .ui-input{border-radius:inherit;background:0 0;border:0;grid-column:2;min-inline-size:0}.ui-input-group .ui-input:focus-visible{outline:none}.ui-input:disabled,.ui-textarea:disabled{border-color:var(--med-color-border-subtle);background:var(--med-color-action-disabled);color:var(--med-color-action-disabled-foreground);cursor:not-allowed}.ui-input[readonly]:not(:disabled),.ui-textarea[readonly]:not(:disabled){border-color:var(--med-color-border-subtle);background:var(--med-color-background-subtle);color:var(--med-color-text-secondary);cursor:default}.ui-input-group[data-disabled=true] .ui-input-group__affordance,.ui-input-group[data-read-only=true] .ui-input-group__affordance{color:var(--med-color-text-disabled)}.ui-input--sm{min-block-size:var(--med-control-height-sm);padding-inline:var(--med-space-3)}.ui-input--md{min-block-size:var(--med-control-height-md)}.ui-input--lg,.ui-input--md{padding-inline:var(--med-space-4)}.ui-input--lg{min-block-size:var(--med-control-height-lg)}.ui-input--error,.ui-textarea--error{border-color:var(--med-color-status-danger-foreground)}.ui-search-icon{border:2px solid var(--med-color-text-muted);border-radius:var(--med-radius-full);block-size:.875rem;inline-size:.875rem;display:block;position:relative}.ui-search-icon:after{background:var(--med-color-text-muted);content:"";transform-origin:50%;block-size:2px;inline-size:.4rem;position:absolute;inset-block-end:-.2rem;inset-inline-end:-.3rem;transform:rotate(45deg)}.ui-textarea{min-block-size:8rem;padding:var(--med-space-3) var(--med-space-4);resize:vertical}.ui-textarea--fixed{resize:none}.ui-badge{align-items:center;gap:var(--med-space-1);min-block-size:1.625rem;padding-inline:var(--med-space-2);border:var(--med-border-default);border-radius:var(--med-radius-full);font-size:var(--med-type-caption-size);font-weight:var(--med-type-weight-semibold);line-height:var(--med-type-caption-leading);white-space:nowrap;display:inline-flex}.ui-badge--neutral{border-color:var(--med-color-border-default);background:var(--med-color-background-subtle);color:var(--med-color-text-secondary)}.ui-badge--brand{border-color:var(--med-color-action-primary-subtle-hover);background:var(--med-color-action-primary-subtle);color:var(--med-color-action-primary-emphasis)}.ui-evidence-badge--moderate,.ui-status-badge--info{border-color:var(--med-color-status-info-border);background:var(--med-color-status-info-subtle);color:var(--med-color-status-info-foreground)}.ui-evidence-badge--strong,.ui-status-badge--success{border-color:var(--med-color-status-success-border);background:var(--med-color-status-success-subtle);color:var(--med-color-status-success-foreground)}.ui-evidence-badge--limited,.ui-status-badge--caution{border-color:var(--med-color-status-caution-border);background:var(--med-color-status-caution-subtle);color:var(--med-color-status-caution-foreground)}.ui-status-badge--danger{border-color:var(--med-color-status-danger-border);background:var(--med-color-status-danger-subtle);color:var(--med-color-status-danger-foreground)}.ui-status-badge__marker{border-radius:var(--med-radius-full);border:1px solid;justify-content:center;align-items:center;block-size:1rem;inline-size:1rem;font-size:.625rem;line-height:1;display:inline-flex}.ui-evidence-badge__marker{font-size:.75rem;line-height:1}.ui-divider{color:var(--med-color-text-muted);align-items:center;display:flex}.ui-divider--horizontal{border-block-start:var(--med-border-default);min-block-size:1px;inline-size:100%}.ui-divider--vertical{min-inline-size:1px;min-block-size:var(--med-touch-target-compact);border-inline-start:var(--med-border-default);align-self:stretch}.ui-divider--labeled{gap:var(--med-space-3);font-size:var(--med-type-caption-size);font-weight:var(--med-type-weight-medium);border:0}.ui-divider--labeled:after,.ui-divider--labeled:before{border-block-start:var(--med-border-default);content:"";flex:1}.ui-divider__label{flex:none}.ui-section-heading{gap:var(--med-space-4);grid-template-columns:auto minmax(0,1fr);align-items:flex-start;inline-size:100%;display:grid}.ui-section-heading__icon{border-radius:var(--med-radius-full);background:var(--med-color-action-primary-subtle);block-size:2.5rem;inline-size:2.5rem;color:var(--med-color-action-primary-emphasis);font-size:var(--med-type-body-size);font-weight:var(--med-type-weight-semibold);justify-content:center;align-items:center;display:inline-flex}.ui-section-heading__content{min-inline-size:0}.ui-accordion__eyebrow,.ui-section-heading__eyebrow{color:var(--med-color-text-muted);font-size:var(--med-type-caption-size);font-weight:var(--med-type-weight-semibold);letter-spacing:var(--med-type-caption-tracking);line-height:var(--med-type-caption-leading);text-transform:uppercase;margin-block-end:var(--med-space-1)}.ui-accordion__title-row,.ui-section-heading__title-row{justify-content:space-between;align-items:baseline;gap:var(--med-space-3) var(--med-space-5);flex-wrap:wrap;min-inline-size:0;display:flex}.ui-section-heading__title{color:var(--med-color-text-primary);font-size:var(--med-type-heading-sm-size);font-weight:var(--med-type-weight-semibold);letter-spacing:var(--med-type-heading-sm-tracking);line-height:var(--med-type-heading-sm-leading);margin:0}.ui-accordion__metadata,.ui-alert__metadata,.ui-definition__metadata,.ui-section-heading__metadata{color:var(--med-color-text-muted);font-size:var(--med-type-caption-size);font-weight:var(--med-type-weight-medium);line-height:var(--med-type-caption-leading)}.ui-section-heading__description{max-inline-size:var(--med-layout-width-reading);color:var(--med-color-text-secondary);font-size:var(--med-type-supporting-size);line-height:var(--med-type-supporting-leading);margin-block-start:var(--med-space-2)}.ui-definition{inline-size:100%;padding:var(--med-space-5);border:var(--med-border-default);border-inline-start:var(--med-border-width-emphasis) var(--med-border-style) var(--med-color-action-primary);border-radius:var(--med-radius-md);background:var(--med-color-background-subtle);margin:0}.ui-definition__entry{gap:var(--med-space-2);display:grid}.ui-definition__term-row{align-items:baseline;gap:var(--med-space-2) var(--med-space-3);flex-wrap:wrap;display:flex}.ui-definition__term{color:var(--med-color-text-primary);font-style:normal;font-weight:var(--med-type-weight-semibold)}.ui-definition__pronunciation{color:var(--med-color-text-muted);font-size:var(--med-type-body-sm-size);line-height:var(--med-type-body-sm-leading)}.ui-definition__description{max-inline-size:var(--med-layout-width-reading);color:var(--med-color-text-secondary);font-size:var(--med-type-body-size);line-height:var(--med-type-body-leading);margin:0}.ui-accordion{border:var(--med-border-default);border-radius:var(--med-radius-lg);background:var(--med-color-background-surface);inline-size:100%;overflow:hidden}.ui-accordion__heading{font:inherit;margin:0}.ui-accordion__trigger{inline-size:100%;min-block-size:var(--med-touch-target-minimum);align-items:center;gap:var(--med-space-3);padding:var(--med-space-4) var(--med-space-5);color:var(--med-color-text-primary);font:inherit;text-align:start;cursor:pointer;transition-property:background-color,color;transition-duration:var(--med-motion-duration-fast);transition-timing-function:var(--med-motion-easing-standard);background:0 0;border:0;grid-template-columns:auto minmax(0,1fr) auto;display:grid}.ui-accordion__trigger:hover:not(:disabled){background:var(--med-color-background-subtle)}.ui-accordion__trigger:disabled{background:var(--med-color-action-disabled);color:var(--med-color-action-disabled-foreground);cursor:not-allowed}.ui-accordion__icon{border-radius:var(--med-radius-full);background:var(--med-color-action-primary-subtle);block-size:2rem;inline-size:2rem;color:var(--med-color-action-primary-emphasis);font-size:var(--med-type-body-sm-size);font-weight:var(--med-type-weight-semibold);justify-content:center;align-items:center;display:inline-flex}.ui-accordion__label{min-inline-size:0}.ui-accordion__title{font-size:var(--med-type-body-size);font-weight:var(--med-type-weight-semibold);line-height:var(--med-type-body-leading)}.ui-accordion__indicator{block-size:.625rem;inline-size:.625rem;transition:transform var(--med-motion-duration-standard) var(--med-motion-easing-standard);border-block-end:2px solid;border-inline-end:2px solid;margin-inline-end:var(--med-space-1);transform:rotate(45deg)}.ui-accordion__trigger[aria-expanded=true] 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button{min-height:var(--med-touch-target-min);padding:var(--med-space-3);color:var(--med-color-text-link);border:var(--med-border-width-default) solid var(--med-color-border-default);border-radius:var(--med-radius-md);font-weight:700}.patient-brief-document{padding:clamp(var(--med-space-6),5vw,var(--med-space-12));color:var(--med-color-text-primary);background:var(--med-color-background-surface);border:var(--med-border-width-default) solid var(--med-color-border-subtle);box-shadow:var(--med-elevation-raised)}.patient-brief-document>header{justify-content:space-between;gap:var(--med-space-5);padding-bottom:var(--med-space-6);border-bottom:.25rem solid var(--med-palette-brand-400);display:flex}.patient-brief-document h2{margin-top:var(--med-space-2);font-size:var(--med-font-size-heading-lg)}.patient-brief-document h3{margin-bottom:var(--med-space-2);font-size:var(--med-font-size-heading-sm)}.patient-brief-document section{margin-block:var(--med-space-7)}.patient-brief-document 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1fr}.patient-brief-review-layout{grid-template-columns:1fr}.patient-brief-review-controls{position:static}}@media (max-width:40rem){.clinical-readiness,.clinical-research-form,.clinical-response-grid,.clinical-saved-list,.clinical-workspace-grid,.patient-brief-columns{grid-template-columns:1fr}.clinical-research-form>.ui-button{white-space:normal;width:100%}.clinical-response>header,.clinical-source-row,.patient-brief-document>header,.patient-brief-list-card{flex-direction:column}.patient-brief-list-card>div:last-child{justify-items:start}}@media print{.app-footer,.app-header,.clinical-page-header,.clinical-status-banner,.patient-brief-review-controls{display:none!important}.clinical-content,.patient-brief-review-layout{padding:0;display:block}.patient-brief-document{box-shadow:none;border:0;padding:0}}body{background:var(--med-color-background-page);color:var(--med-color-text-primary);font-family:var(--med-font-family-sans);font-synthesis:none}@property --tw-space-y-reverse{syntax:"*";inherits:false;initial-value:0}@property --tw-border-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-font-weight{syntax:"*";inherits:false}@property --tw-ordinal{syntax:"*";inherits:false}@property --tw-slashed-zero{syntax:"*";inherits:false}@property --tw-numeric-figure{syntax:"*";inherits:false}@property --tw-numeric-spacing{syntax:"*";inherits:false}@property --tw-numeric-fraction{syntax:"*";inherits:false}@property --tw-blur{syntax:"*";inherits:false}@property --tw-brightness{syntax:"*";inherits:false}@property --tw-contrast{syntax:"*";inherits:false}@property --tw-grayscale{syntax:"*";inherits:false}@property --tw-hue-rotate{syntax:"*";inherits:false}@property --tw-invert{syntax:"*";inherits:false}@property --tw-opacity{syntax:"*";inherits:false}@property --tw-saturate{syntax:"*";inherits:false}@property --tw-sepia{syntax:"*";inherits:false}@property --tw-drop-shadow{syntax:"*";inherits:false}@property --tw-drop-shadow-color{syntax:"*";inherits:false}@property --tw-drop-shadow-alpha{syntax:"<percentage>";inherits:false;initial-value:100%}@property --tw-drop-shadow-size{syntax:"*";inherits:false}